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Search Results for " egfr/erbb-2 inhibitor-1 "

9

Compounds

Cat No. Product Name Synonyms Targets
T79861 EGFR/ErbB-2 inhibitor-1 EGFR
EGFR/ErbB-2 inhibitor-1 is a selective ErbB2/HER2 inhibitor that effectively blocks ErbB2 and HER2 signaling.
T21954 EGFR/ErbB-2/ErbB-4 inhibitor-2 EGFR/ErbB2 Inhibitor EGFR
EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)
T9927 Panitumumab EGFR
Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).
T22431 SU5204 3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one EGFR , VEGFR , HER
SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and HER2)
T6427 Butein 2’,3,4,4’-tetrahydroxy Chalcone Apoptosis , EGFR , Others , PDE , Autophagy
Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.
T9304 (S)-Sunvozertinib N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008 EGFR , HER
(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.
T21312 Afatinib Afatinib free base,BIBW 2992 EGFR , Autophagy
Afatinib (BIBW 2992) is an irreversible inhibitor of EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M and HER2 with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM , respectively).
T2851 Daphnetin 7,8-Dihydroxycoumarin,Daphnetol EGFR , PKA , PKC , Parasite , Autophagy
Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-...
T1773 Afatinib Dimaleate BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate EGFR , HER , Autophagy
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic act...
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